(Microbial Diversity and Bioinformatics)
時間：2021. 10. 06 Wed. 09:00
地 點：跨領域科技研究大樓 1 樓 C101 會議室
Associate Research Scientist
Department of Molecular, Yale University
講題：Dynamic Information Processing by Microbial Signaling Pathways
Cells are highly sophisticated sensorimotor systems, dynamically adapting their behavior to their surrounding environment. Underlying this adaptation is continuous processing of environmental signals and real-time control of behavioral outputs by signaling pathways. Despite the intense molecular characterizations of the representative signaling pathways in model organisms, we have yet to grasp a clear set of principles of cellular information processing. In the first part of the seminar, I will talk about how investigations into cellular signaling dynamics have helped us gain insights into functions of signaling pathways. Focusing on my recent work (Kamino et al., Sci. Adv., 2020; Mattingly* and Kamino* et al., Nat. Phys., in press, *equal contribution), I will explain how the combination of live-cell imaging, particularly single-cell FRET imaging, and mathematical modeling has revealed fundamental properties of the E. coli chemotaxis pathway. In the second part, I will talk about my future research plan in which experimental tools developed and tested in E. coli chemotaxis will be translated for use in other bacteria to investigate the diverse world of microbial signal processing.